Title : The selective COX-2 inhibitor celecoxib modulates sphingolipid synthesis.

Pub. Date : 2009 Jan

PMID : 18711209






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Celecoxib inhibited the dihydroceramide desaturase (DEGS) in vivo with an IC(50) of 78.9 +/- 1.5 muM and increased total Cer level about 2-fold, indicating an activation of sphingolipid biosynthesis. Sphingolipids delta 4-desaturase, sphingolipid 1 Homo sapiens