Pub. Date : 2008 Jul 5
PMID : 18710638
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: This study investigated the inhibitory effect of berberine (BBR) on lipopolysaccharide (LPS) induced cyclooxygenase-2 (COX-2) expression via the mitogen activated protein kinase (MAPK) signalling cascade pathways in human peripheral blood monocytes (PBMC). | Berberine | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | With BBR treatment for 6, 12 or 24 hours at three doses, ERK1/2 protein expression was significantly inhibited. | Berberine | mitogen-activated protein kinase 3 | Homo sapiens |
| 3 | CONCLUSIONS: Berberine inhibits COX-2 expression via the ERK1/2 signalling pathway and, possibly, at a high dosage via the JNK pathway. | Berberine | mitogen-activated protein kinase 3 | Homo sapiens |