Pub. Date : 2008 Aug 15
PMID : 18701484
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show here that K-Ras.GTP recruits Galectin-3 (Gal-3) from the cytosol to the plasma membrane where it becomes an integral nanocluster component. | Guanosine Triphosphate | KRAS proto-oncogene, GTPase | Homo sapiens |
| 2 | Importantly, we show that the cytosolic level of Gal-3 determines the magnitude of K-Ras.GTP nanoclustering and signal output. | Guanosine Triphosphate | KRAS proto-oncogene, GTPase | Homo sapiens |
| 3 | Gal-3(V125A) interaction with K-Ras.GTP reduces K-Ras.GTP nanocluster formation, which abrogates signal output from the Raf/mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK; MEK) pathway. | Guanosine Triphosphate | KRAS proto-oncogene, GTPase | Homo sapiens |
| 4 | Gal-3(V125A) interaction with K-Ras.GTP reduces K-Ras.GTP nanocluster formation, which abrogates signal output from the Raf/mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK; MEK) pathway. | Guanosine Triphosphate | KRAS proto-oncogene, GTPase | Homo sapiens |
| 5 | Gal-3(V125A) interaction with K-Ras.GTP reduces K-Ras.GTP nanocluster formation, which abrogates signal output from the Raf/mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK; MEK) pathway. | Guanosine Triphosphate | KRAS proto-oncogene, GTPase | Homo sapiens |
| 6 | Gal-3(V125A) interaction with K-Ras.GTP reduces K-Ras.GTP nanocluster formation, which abrogates signal output from the Raf/mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK; MEK) pathway. | Guanosine Triphosphate | KRAS proto-oncogene, GTPase | Homo sapiens |