Title : Impaired anaplerosis and insulin secretion in insulinoma cells caused by small interfering RNA-mediated suppression of pyruvate carboxylase.

Pub. Date : 2008 Oct 17

PMID : 18697738






3 Functional Relationships(s)
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Protein Name
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1 Consistent with a block at PC, the most PC-deficient cells showed a metabolic crossover point at PC with increased basal and/or glucose-stimulated pyruvate plus lactate and decreased malate and citrate. Glucose pyruvate carboxylase Homo sapiens
2 Consistent with a block at PC, the most PC-deficient cells showed a metabolic crossover point at PC with increased basal and/or glucose-stimulated pyruvate plus lactate and decreased malate and citrate. Glucose pyruvate carboxylase Homo sapiens
3 The results confirm the central importance of PC and anaplerosis to generate metabolites from glucose that support insulin secretion and even suggest PC is important for insulin secretion stimulated by noncarbohydrate insulin secretagogues. Glucose pyruvate carboxylase Homo sapiens