Title : The role of Dickkopf-1 in bone development, homeostasis, and disease.

Pub. Date : 2009 Jan 15

PMID : 18687985






1 Functional Relationships(s)
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1 Studies suggest that DKK1 activation in osteoblasts is the underlying cause of glucocorticoid- and estrogen deficiency-mediated osteoporosis, and at least partially underlies the teratogenic effects of thalidomide on limb development. Thalidomide dickkopf WNT signaling pathway inhibitor 1 Homo sapiens