Protein Name dickkopf WNT signaling pathway inhibitor 1
Organism Homo sapiens
Gene ID 22943
Gene Symbol

DKK1

UniProt O94907 (DKK1_HUMAN), I1W660 (I1W660_HUMAN)
Relationships Total Number of functionally related compound(s) : 264
Total Number of Articles : 323
Description

dickkopf WNT signaling pathway inhibitor 1

Gene Summary

This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017]

synonyms
  • dickkopf-related protein 1
  • dickkopf 1 homolog
  • dickkopf-1 like
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Properties