Title : Recognition of NY-ESO-1+ tumor cells by engineered lymphocytes is enhanced by improved vector design and epigenetic modulation of tumor antigen expression.

Pub. Date : 2009 Mar

PMID : 18677478






1 Functional Relationships(s)
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1 Induction of NY-ESO-1 expression on tumor targets using the demethylating agent 5-aza-2"-deoxycytidine (alone or in combination with the histone deacetylase inhibitor depsipeptide) resulted in enhanced interferon-gamma secretion by the TCR-transduced PBL on culture with treated targets. Depsipeptides interferon gamma Homo sapiens