Pub. Date : 2008 Aug 1
PMID : 18676837
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BRAF V600E disrupts AZD6244-induced abrogation of negative feedback pathways between extracellular signal-regulated kinase and Raf proteins. | AZD 6244 | B-Raf proto-oncogene, serine/threonine kinase | Homo sapiens |
| 2 | AZD6244 induced G(0)-G(1) cell cycle arrest in sensitive cell lines that primarily included cells containing the BRAF V600E mutation. | AZD 6244 | B-Raf proto-oncogene, serine/threonine kinase | Homo sapiens |
| 3 | In the majority of cell lines tested, including those with K-ras or non-V600E BRAF mutations, AZD6244 induced the accumulation of phospho-MEK, an effect not observed in the most sensitive BRAF V600E-containing cells. | AZD 6244 | B-Raf proto-oncogene, serine/threonine kinase | Homo sapiens |
| 4 | In the majority of cell lines tested, including those with K-ras or non-V600E BRAF mutations, AZD6244 induced the accumulation of phospho-MEK, an effect not observed in the most sensitive BRAF V600E-containing cells. | AZD 6244 | B-Raf proto-oncogene, serine/threonine kinase | Homo sapiens |
| 5 | Specific suppression of endogenous BRAF V600E does not confer resistance to AZD6244 but enhances sensitivity to AZD6244. | AZD 6244 | B-Raf proto-oncogene, serine/threonine kinase | Homo sapiens |