Pub. Date : 2008 Aug 6
PMID : 18664652
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We examined the efficacy of lapatinib, an inhibitor of the epidermal growth factor receptor (EGFR) and HER2 kinases, for preventing the outgrowth of breast cancer cells in the brain in a mouse xenograft model of brain metastasis. | Lapatinib | erb-b2 receptor tyrosine kinase 2 | Mus musculus |
| 2 | RESULTS: In vitro, lapatinib inhibited the phosphorylation of EGFR, HER2, and downstream signaling proteins; cell proliferation; and migration in 231-BR cells (both with and without HER2). | Lapatinib | erb-b2 receptor tyrosine kinase 2 | Mus musculus |
| 3 | RESULTS: In vitro, lapatinib inhibited the phosphorylation of EGFR, HER2, and downstream signaling proteins; cell proliferation; and migration in 231-BR cells (both with and without HER2). | Lapatinib | erb-b2 receptor tyrosine kinase 2 | Mus musculus |
| 4 | Immunohistochemical analysis revealed reduced phosphorylation of HER2 in 231-BR-HER2 cell-derived brain metastases from mice treated with the higher dose of lapatinib compared with 231-BR-HER2 cell-derived brain metastases from vehicle-treated mice (P < .001). | Lapatinib | erb-b2 receptor tyrosine kinase 2 | Mus musculus |
| 5 | Immunohistochemical analysis revealed reduced phosphorylation of HER2 in 231-BR-HER2 cell-derived brain metastases from mice treated with the higher dose of lapatinib compared with 231-BR-HER2 cell-derived brain metastases from vehicle-treated mice (P < .001). | Lapatinib | erb-b2 receptor tyrosine kinase 2 | Mus musculus |
| 6 | Immunohistochemical analysis revealed reduced phosphorylation of HER2 in 231-BR-HER2 cell-derived brain metastases from mice treated with the higher dose of lapatinib compared with 231-BR-HER2 cell-derived brain metastases from vehicle-treated mice (P < .001). | Lapatinib | erb-b2 receptor tyrosine kinase 2 | Mus musculus |
| 7 | CONCLUSIONS: Lapatinib is the first HER2-directed drug to be validated in a preclinical model for activity against brain metastases of breast cancer. | Lapatinib | erb-b2 receptor tyrosine kinase 2 | Mus musculus |