Title : Impaired glucose-stimulated insulin secretion in the GK rat is associated with abnormalities in islet nitric oxide production.

Pub. Date : 2008 Nov 29

PMID : 18662725






3 Functional Relationships(s)
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1 After incubation at low glucose GK islets showed an abnormal increase in both iNOS and ncNOS activities. Glucose nitric oxide synthase 2 Rattus norvegicus
2 At high glucose the impaired glucose-stimulated insulin release was associated with an increased iNOS expression and activity and NOS inhibition dose-dependently amplified insulin secretion in both GK and control islets. Glucose nitric oxide synthase 2 Rattus norvegicus
3 At high glucose the impaired glucose-stimulated insulin release was associated with an increased iNOS expression and activity and NOS inhibition dose-dependently amplified insulin secretion in both GK and control islets. Glucose nitric oxide synthase 2 Rattus norvegicus