Pub. Date : 2009 May
PMID : 18656336
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tea polyphenols can restrict benzo[a]pyrene-induced lung carcinogenesis by altered expression of p53-associated genes and H-ras, c-myc and cyclin D1. | Polyphenols | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | Mus musculus |
| 2 | Progression of lung lesions was restricted at the hyperplastic stage by tea polyphenols. | Polyphenols | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | Mus musculus |
| 3 | The tea polyphenols inhibited inflammatory response in the lung lesions on the 9th week, when decreased expression of H-ras and c-myc and increased expression of bax were noted. | Polyphenols | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | Mus musculus |
| 4 | Prolonged treatment (>9th week) with tea polyphenols resulted in changes in the expression of some additional genes, such as reduced expression of cyclin D1 (from the 17th week), bcl-2 (from the 26th week; mild dysplasia) and p21 (on the 36th week), and high expression of p53 (from the 17th week) and p27 (on the 36th week). | Polyphenols | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | Mus musculus |
| 5 | These observations indicate that the tea polyphenols can restrict B[a]P-induced lung carcinogenesis by differential modulation of the expression of p53 and its associated genes such as bax, bcl-2, mdm2, p21 and p27, along with H-ras, c-myc and cyclin D1, at different time points. | Polyphenols | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | Mus musculus |