Title : Histone deacetylase inhibitor-induced cellular apoptosis involves stanniocalcin-1 activation.

Pub. Date : 2008 Oct 1

PMID : 18652825






4 Functional Relationships(s)
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1 A cotreatment of HT29 cells with a NFkappaB inhibitor (parthenolide) significantly inhibited the TSA-induced cellular levels of acetyl NFkappaB p65 and abolished the stimulation of STC1 gene expression. parthenolide stanniocalcin 1 Homo sapiens
2 ChIP assay also demonstrated that TSA treatment increased while TSA/parthenolide cotreatment decreased NFkappaB p65 binding to STC1 gene promoter. parthenolide stanniocalcin 1 Homo sapiens
3 Consistent with the STC1mRNA expression data, TSA/parthenolide cotreatment also significantly inhibited the TSA-induced STC1 promoter-driven luciferase activity. parthenolide stanniocalcin 1 Homo sapiens
4 Consistent with the STC1mRNA expression data, TSA/parthenolide cotreatment also significantly inhibited the TSA-induced STC1 promoter-driven luciferase activity. parthenolide stanniocalcin 1 Homo sapiens