| Protein Name | stanniocalcin 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 6781 |
| Gene Symbol | STC1 |
| UniProt | P52823 (STC1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
177
Total Number of Articles : 184 |
Description |
stanniocalcin 1 |
| Gene Summary |
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008] |
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