Title : Pharmacological inhibitors of JNK and ERK kinases SP600125 and U0126 are not appropriate tools for studies of drug metabolism because they activate aryl hydrocarbon receptor.

Pub. Date : 2008 Jun

PMID : 18645229






2 Functional Relationships(s)
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1 Pharmacological inhibitors of JNK and ERK kinases SP600125 and U0126 are not appropriate tools for studies of drug metabolism because they activate aryl hydrocarbon receptor. U 0126 mitogen-activated protein kinase 8 Homo sapiens
2 Unfortunately, the inhibitors of JNK and ERK MAPKs, i.e. SP600125 and U0126, respectively, affect AhR-CYP1A signaling pathway because they are partial agonists of AhR and induce CYP1A genes. U 0126 mitogen-activated protein kinase 8 Homo sapiens