Pub. Date : 2008 Jul
PMID : 18645031
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine. | Vinblastine | BCL2 antagonist/killer 1 | Homo sapiens |
| 2 | Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine. | Vinblastine | BCL2 antagonist/killer 1 | Homo sapiens |
| 3 | In this study, we investigated the role of Bak in vinblastine-induced apoptosis. | Vinblastine | BCL2 antagonist/killer 1 | Homo sapiens |
| 4 | Bak was mainly monomeric in untreated KB-3 cells, and multimers corresponding to dimer, trimer, and higher oligomers were observed after vinblastine treatment. | Vinblastine | BCL2 antagonist/killer 1 | Homo sapiens |
| 5 | Immunoprecipitation with a conformation-dependent Bak antibody revealed that vinblastine induced Bak activation. | Vinblastine | BCL2 antagonist/killer 1 | Homo sapiens |
| 6 | Immunoprecipitation with a conformation-dependent Bak antibody revealed that vinblastine induced Bak activation. | Vinblastine | BCL2 antagonist/killer 1 | Homo sapiens |
| 7 | Reciprocal immunoprecipitations indicated that vinblastine induced the interaction of active Bak with active Bax. | Vinblastine | BCL2 antagonist/killer 1 | Homo sapiens |
| 8 | These results highlight Bak as a key mediator of vinblastine-induced apoptosis and show for the first time activation and oligomerization of Bak by an antimitotic agent. | Vinblastine | BCL2 antagonist/killer 1 | Homo sapiens |