Title : N1421K mutation in the glycoprotein Ib binding domain impairs ristocetin- and botrocetin-mediated binding of von Willebrand factor to platelets.

Pub. Date : 2008 Nov

PMID : 18637125






3 Functional Relationships(s)
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Protein Name
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1 N1421K mutation in the glycoprotein Ib binding domain impairs ristocetin- and botrocetin-mediated binding of von Willebrand factor to platelets. Ristocetin von Willebrand factor Homo sapiens
2 Botrocetin- and ristocetin-mediated binding of plasma VWF to GPIb were reduced in the patients. Ristocetin von Willebrand factor Homo sapiens
3 In vitro mutagenesis and expression in COS-7 cells confirmed the impairment of the mutant in botrocetin- and ristocetin-mediated VWF binding to GPIb. Ristocetin von Willebrand factor Homo sapiens