Title : Role of Sox-9, ER81 and VE-cadherin in retinoic acid-mediated trans-differentiation of breast cancer cells.

Pub. Date : 2008 Jul 16

PMID : 18628953






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 RA induces expression of many endothelial genes including vascular endothelial (VE) cadherin. Tretinoin cadherin 5 Homo sapiens
2 VE-cadherin was also induced by RA in a number of other breast cancer cells. Tretinoin cadherin 5 Homo sapiens
3 We show that RA-induced VE-cadherin is responsible for the RA-induced morphological changes. Tretinoin cadherin 5 Homo sapiens
4 We show that RA-induced VE-cadherin is responsible for the RA-induced morphological changes. Tretinoin cadherin 5 Homo sapiens
5 RA rapidly induced the expression of Sox-9 and ER81, which in turn form a complex on the VE-cadherin promoter and are required to mediate the transcriptional regulation of VE-cadherin by RA. Tretinoin cadherin 5 Homo sapiens
6 RA rapidly induced the expression of Sox-9 and ER81, which in turn form a complex on the VE-cadherin promoter and are required to mediate the transcriptional regulation of VE-cadherin by RA. Tretinoin cadherin 5 Homo sapiens