Title : The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase.

Pub. Date : 2008 Aug 1

PMID : 18621524






2 Functional Relationships(s)
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1 The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase. furan B-Raf proto-oncogene, serine/threonine kinase Homo sapiens
2 Modification of the potent imidazole-based B-Raf inhibitor SB-590885 resulted in the identification of a series of furan-based derivatives with enhanced CNS penetration. furan B-Raf proto-oncogene, serine/threonine kinase Homo sapiens