Title : Chemosensitisation by manganese superoxide dismutase inhibition is caspase-9 dependent and involves extracellular signal-regulated kinase 1/2.

Pub. Date : 2008 Jul 22

PMID : 18594523






1 Functional Relationships(s)
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Protein Name
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1 Knockdown of MnSOD by small-interfering RNA (siRNA) led to an increase in superoxide generation and sensitisation of ovarian cancer cells to the two front-line anti-cancer agents doxorubicin and paclitaxel whose action involved free-radical generation. Free Radicals superoxide dismutase 2 Homo sapiens