Pub. Date : 2008 Jun 30
PMID : 18587265
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cytosolic accumulation of gammaH2AX is associated with tropomyosin-related kinase A-induced cell death in U2OS cells. | gammah2ax | neurotrophic receptor tyrosine kinase 1 | Homo sapiens |
| 2 | In this study, we also reveal that gammaH2AX production by TrkA is blocked by TrkA kinase inhibitors K-252a and GW441756, and it is also significantly inhibited by JNK inhibitor SP600125. | gammah2ax | neurotrophic receptor tyrosine kinase 1 | Homo sapiens |
| 3 | In this study, we also reveal that gammaH2AX production by TrkA is blocked by TrkA kinase inhibitors K-252a and GW441756, and it is also significantly inhibited by JNK inhibitor SP600125. | gammah2ax | neurotrophic receptor tyrosine kinase 1 | Homo sapiens |
| 4 | We also found that gammaH2AX and TrkA were colocalized in cytosol in the absence of DNA damage, and the nuclear localization of gammaH2AX induced by DNA damage was partly altered to cytosol by TrkA overexpression. | gammah2ax | neurotrophic receptor tyrosine kinase 1 | Homo sapiens |
| 5 | Our results suggest that the abnormal cytosolic accumulation of gammaH2AX is implicated in TrkA-induced cell death in the absence of DNA damage. | gammah2ax | neurotrophic receptor tyrosine kinase 1 | Homo sapiens |