Title : Frequency modulation of synchronized Ca(2+) spikes in cultured hippocampal networks through mTOR.

Pub. Date : 2008 Aug 15

PMID : 18586400






1 Functional Relationships(s)
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1 By using calcium imaging and patch-clamping techniques to study the role of this signaling pathway in the activity of cultured hippocampal neurons, we found that rapamycin significantly reduces the spontaneous activities of network neurons as well as the efficacy of synaptic transmission through insulin-mTOR signaling pathway. Sirolimus insulin Homo sapiens