Pub. Date : 2008 Jul 18
PMID : 18586278
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells. | gambogic acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | We also revealed that phosphorylation levels of p38 and c-Jun N-terminal kinase-1 (JNK-1) were increased markedly by GA, resulting in apoptosis of MCF-7 cells. | gambogic acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | We also revealed that phosphorylation levels of p38 and c-Jun N-terminal kinase-1 (JNK-1) were increased markedly by GA, resulting in apoptosis of MCF-7 cells. | gambogic acid | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Taken together, our results suggested that GA depolymerized microtubules and elevated the phosphorylation levels of JNK1 and p38, which caused G2/M cell cycle arrest and apoptosis in MCF-7 cells. | gambogic acid | mitogen-activated protein kinase 8 | Homo sapiens |