Title : Resveratrol disrupts peroxynitrite-triggered mitochondrial apoptotic pathway: a role for Bcl-2.

Pub. Date : 2008 Aug

PMID : 18584328






4 Functional Relationships(s)
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1 Resveratrol disrupts peroxynitrite-triggered mitochondrial apoptotic pathway: a role for Bcl-2. Resveratrol BCL2 apoptosis regulator Homo sapiens
2 This ratio decreased when cells where pre-incubated with 10 and 50 muM resveratrol, mainly due to resveratrol ability per se to increase Bcl-2 intracellular levels without affecting Bax intracellular levels. Resveratrol BCL2 apoptosis regulator Homo sapiens
3 This ratio decreased when cells where pre-incubated with 10 and 50 muM resveratrol, mainly due to resveratrol ability per se to increase Bcl-2 intracellular levels without affecting Bax intracellular levels. Resveratrol BCL2 apoptosis regulator Homo sapiens
4 These results propose an additional mechanism whereby resveratrol may exert its cardioprotective effects and suggest a key role for Bcl-2 in the resveratrol anti-apoptotic action, especially in disrupting peroxynitrite-triggered mitochondrial pathway. Resveratrol BCL2 apoptosis regulator Homo sapiens