Pub. Date : 2008 Sep
PMID : 18583454
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Long-term nicotine treatment differentially regulates striatal alpha6alpha4beta2* and alpha6(nonalpha4)beta2* nAChR expression and function. | Nicotine | cholinergic receptor nicotinic alpha 2 subunit | Rattus norvegicus |
| 2 | Nicotine treatment has long been associated with alterations in alpha4beta2(*) nicotinic acetylcholine receptor (nAChR) expression that modify dopaminergic function. | Nicotine | cholinergic receptor nicotinic alpha 2 subunit | Rattus norvegicus |
| 3 | Nicotine treatment has long been associated with alterations in alpha4beta2(*) nicotinic acetylcholine receptor (nAChR) expression that modify dopaminergic function. | Nicotine | cholinergic receptor nicotinic alpha 2 subunit | Rattus norvegicus |
| 4 | However, the influence of long-term nicotine treatment on the alpha6beta2(*) nAChR, a subtype specifically localized on dopaminergic neurons, is less clear. | Nicotine | cholinergic receptor nicotinic alpha 2 subunit | Rattus norvegicus |
| 5 | Here we used voltammetry, as well as receptor binding studies, to identify the effects of nicotine on striatal alpha6beta2(*) nAChR function and expression. | Nicotine | cholinergic receptor nicotinic alpha 2 subunit | Rattus norvegicus |
| 6 | In contrast, in nicotine-treated rats, alpha6beta2(*) nAChR blockade elicited a similar pattern of dopamine release with nonburst and burst firing. | Nicotine | cholinergic receptor nicotinic alpha 2 subunit | Rattus norvegicus |
| 7 | (125)I-alpha-CtxMII competition studies in striatum of knockout mice showed that nicotine treatment decreased the alpha6alpha4beta2(*) subtype but increased the alpha6(nonalpha4)beta2(*) nAChR population. | Nicotine | cholinergic receptor nicotinic alpha 2 subunit | Rattus norvegicus |
| 8 | These data indicate that alpha6beta2(*) nAChR-evoked dopamine release in nicotine-treated rats is mediated by the alpha6(nonalpha4)beta2(*) nAChR subtype and suggest that the alpha6alpha4beta2(*) nAChR and/or alpha4beta2(*) nAChR contribute to the differential effect of higher frequency stimulation on dopamine release under control conditions. | Nicotine | cholinergic receptor nicotinic alpha 2 subunit | Rattus norvegicus |
| 9 | These data indicate that alpha6beta2(*) nAChR-evoked dopamine release in nicotine-treated rats is mediated by the alpha6(nonalpha4)beta2(*) nAChR subtype and suggest that the alpha6alpha4beta2(*) nAChR and/or alpha4beta2(*) nAChR contribute to the differential effect of higher frequency stimulation on dopamine release under control conditions. | Nicotine | cholinergic receptor nicotinic alpha 2 subunit | Rattus norvegicus |
| 10 | These data indicate that alpha6beta2(*) nAChR-evoked dopamine release in nicotine-treated rats is mediated by the alpha6(nonalpha4)beta2(*) nAChR subtype and suggest that the alpha6alpha4beta2(*) nAChR and/or alpha4beta2(*) nAChR contribute to the differential effect of higher frequency stimulation on dopamine release under control conditions. | Nicotine | cholinergic receptor nicotinic alpha 2 subunit | Rattus norvegicus |
| 11 | These data indicate that alpha6beta2(*) nAChR-evoked dopamine release in nicotine-treated rats is mediated by the alpha6(nonalpha4)beta2(*) nAChR subtype and suggest that the alpha6alpha4beta2(*) nAChR and/or alpha4beta2(*) nAChR contribute to the differential effect of higher frequency stimulation on dopamine release under control conditions. | Nicotine | cholinergic receptor nicotinic alpha 2 subunit | Rattus norvegicus |