PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18583454-0	2008	Long-term nicotine treatment differentially regulates striatal alpha6alpha4beta2* and alpha6(nonalpha4)beta2* nAChR expression and function.	Nicotine	10-18	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	110-115	
18583454-1	2008	Nicotine treatment has long been associated with alterations in alpha4beta2(*) nicotinic acetylcholine receptor (nAChR) expression that modify dopaminergic function.	Nicotine	0-8	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	79-111	
18583454-1	2008	Nicotine treatment has long been associated with alterations in alpha4beta2(*) nicotinic acetylcholine receptor (nAChR) expression that modify dopaminergic function.	Nicotine	0-8	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	113-118	
18583454-2	2008	However, the influence of long-term nicotine treatment on the alpha6beta2(*) nAChR, a subtype specifically localized on dopaminergic neurons, is less clear.	Nicotine	36-44	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	77-82	
18583454-3	2008	Here we used voltammetry, as well as receptor binding studies, to identify the effects of nicotine on striatal alpha6beta2(*) nAChR function and expression.	Nicotine	90-98	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	126-131	
18583454-7	2008	In contrast, in nicotine-treated rats, alpha6beta2(*) nAChR blockade elicited a similar pattern of dopamine release with nonburst and burst firing.	Nicotine	16-24	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	54-59	
18583454-9	2008	(125)I-alpha-CtxMII competition studies in striatum of knockout mice showed that nicotine treatment decreased the alpha6alpha4beta2(*) subtype but increased the alpha6(nonalpha4)beta2(*) nAChR population.	Nicotine	81-89	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	187-192	
18583454-10	2008	These data indicate that alpha6beta2(*) nAChR-evoked dopamine release in nicotine-treated rats is mediated by the alpha6(nonalpha4)beta2(*) nAChR subtype and suggest that the alpha6alpha4beta2(*) nAChR and/or alpha4beta2(*) nAChR contribute to the differential effect of higher frequency stimulation on dopamine release under control conditions.	Nicotine	73-81	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	40-45	
18583454-10	2008	These data indicate that alpha6beta2(*) nAChR-evoked dopamine release in nicotine-treated rats is mediated by the alpha6(nonalpha4)beta2(*) nAChR subtype and suggest that the alpha6alpha4beta2(*) nAChR and/or alpha4beta2(*) nAChR contribute to the differential effect of higher frequency stimulation on dopamine release under control conditions.	Nicotine	73-81	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	140-145	
18583454-10	2008	These data indicate that alpha6beta2(*) nAChR-evoked dopamine release in nicotine-treated rats is mediated by the alpha6(nonalpha4)beta2(*) nAChR subtype and suggest that the alpha6alpha4beta2(*) nAChR and/or alpha4beta2(*) nAChR contribute to the differential effect of higher frequency stimulation on dopamine release under control conditions.	Nicotine	73-81	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	140-145	
18583454-10	2008	These data indicate that alpha6beta2(*) nAChR-evoked dopamine release in nicotine-treated rats is mediated by the alpha6(nonalpha4)beta2(*) nAChR subtype and suggest that the alpha6alpha4beta2(*) nAChR and/or alpha4beta2(*) nAChR contribute to the differential effect of higher frequency stimulation on dopamine release under control conditions.	Nicotine	73-81	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	140-145