Title : Smoking reduces serum levels of lamotrigine.

Pub. Date : 2008 Oct

PMID : 18583161






1 Functional Relationships(s)
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1 Our data indicate that the demonstrated effect of smoking on LTG metabolism is likely to be mediated via UDPGT2B7, as LTG is not a substrate of cytochrome P450 isoenzymes and UDPGT1A4 activity may not be affected by nicotine, but the exact mechanism underlying the demonstrated effect remains uncertain. Nicotine UDP glucuronosyltransferase family 2 member B7 Homo sapiens