Title : CD44-epidermal growth factor receptor interaction mediates hyaluronic acid-promoted cell motility by activating protein kinase C signaling involving Akt, Rac1, Phox, reactive oxygen species, focal adhesion kinase, and MMP-2.

Pub. Date : 2008 Aug 15

PMID : 18577517






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 CD44-epidermal growth factor receptor interaction mediates hyaluronic acid-promoted cell motility by activating protein kinase C signaling involving Akt, Rac1, Phox, reactive oxygen species, focal adhesion kinase, and MMP-2. Reactive Oxygen Species epidermal growth factor receptor Homo sapiens
2 EGFR-Akt interaction promoted by HA was responsible for the increased production of ROS and HA-promoted cell motility. Reactive Oxygen Species epidermal growth factor receptor Homo sapiens
3 In summary, HA promotes CD44-EGFR interaction, which in turn activates PKC signaling, involving Akt, Rac1, Phox, and the production of ROS, FAK, and MMP-2, to enhance melanoma cell motility. Reactive Oxygen Species epidermal growth factor receptor Homo sapiens