Title : Effects of remifentanyl and fentanyl on LPS-induced cytokine release in human whole blood in vitro.

Pub. Date : 2009 May

PMID : 18575957






4 Functional Relationships(s)
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1 Aim The present study sought insight into the effects of remifentanyl and fentanyl on LPS-induced release of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and IL-10 in human whole blood. Remifentanil interleukin 6 Homo sapiens
2 IL-6, TNF-alpha and IL-10 concentrations in activation groups treated with remifentanyl or fentanyl were significantly lower than those in LPS treated group (P < 0.05). Remifentanil interleukin 6 Homo sapiens
3 Conclusion Remifentanyl or fentanyl alone has no effects on IL-6, TNF-alpha and IL-10 production, but could attenuate LPS-induced IL-6,TNF-alpha and IL-10 production in human whole blood. Remifentanil interleukin 6 Homo sapiens
4 Remifentanyl and fentanyl could inhibit the expressions of IL-6, TNF-alpha and IL-10 induced by LPS. Remifentanil interleukin 6 Homo sapiens