Pub. Date : 2008 Nov 1
PMID : 18567639
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Insulin-like growth factor-I induces reactive oxygen species production and cell migration through Nox4 and Rac1 in vascular smooth muscle cells. | Reactive Oxygen Species | insulin-like growth factor 1 | Rattus norvegicus |
| 2 | AIMS: We showed previously that insulin-like growth factor-I (IGF-I)-induced vascular smooth muscle cells (VSMCs) proliferation through the production of reactive oxygen species (ROS). | Reactive Oxygen Species | insulin-like growth factor 1 | Rattus norvegicus |
| 3 | AIMS: We showed previously that insulin-like growth factor-I (IGF-I)-induced vascular smooth muscle cells (VSMCs) proliferation through the production of reactive oxygen species (ROS). | Reactive Oxygen Species | insulin-like growth factor 1 | Rattus norvegicus |
| 4 | AIMS: We showed previously that insulin-like growth factor-I (IGF-I)-induced vascular smooth muscle cells (VSMCs) proliferation through the production of reactive oxygen species (ROS). | Reactive Oxygen Species | insulin-like growth factor 1 | Rattus norvegicus |
| 5 | AIMS: We showed previously that insulin-like growth factor-I (IGF-I)-induced vascular smooth muscle cells (VSMCs) proliferation through the production of reactive oxygen species (ROS). | Reactive Oxygen Species | insulin-like growth factor 1 | Rattus norvegicus |
| 6 | However, how IGF-I-induced ROS was unknown. | Reactive Oxygen Species | insulin-like growth factor 1 | Rattus norvegicus |
| 7 | The aim of this study is to investigate the mechanisms by which IGF-I induces ROS production in VSMCs. | Reactive Oxygen Species | insulin-like growth factor 1 | Rattus norvegicus |
| 8 | VSMCs from Sprague-Dawley rat thoracic aortas were used in this work.IGF-I enhanced ROS production in rat VSMCs. | Reactive Oxygen Species | insulin-like growth factor 1 | Rattus norvegicus |
| 9 | Either knockdown of Nox4 or inactivation of Rac1 impaired IGF-I-induced ROS. | Reactive Oxygen Species | insulin-like growth factor 1 | Rattus norvegicus |
| 10 | CONCLUSION: Our results suggest that Nox4 and Rac1 mediate IGF-I-induced ROS production and cell migration in VSMCs and that Nox4 is not regulated by Rac1. | Reactive Oxygen Species | insulin-like growth factor 1 | Rattus norvegicus |