Pub. Date : 2008 Nov 1
PMID : 18567639
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Insulin-like growth factor-I induces reactive oxygen species production and cell migration through Nox4 and Rac1 in vascular smooth muscle cells. | Reactive Oxygen Species | Rac family small GTPase 1 | Rattus norvegicus |
| 2 | Either knockdown of Nox4 or inactivation of Rac1 impaired IGF-I-induced ROS. | Reactive Oxygen Species | Rac family small GTPase 1 | Rattus norvegicus |
| 3 | CONCLUSION: Our results suggest that Nox4 and Rac1 mediate IGF-I-induced ROS production and cell migration in VSMCs and that Nox4 is not regulated by Rac1. | Reactive Oxygen Species | Rac family small GTPase 1 | Rattus norvegicus |