Pub. Date : 2008 Jul 1
PMID : 18566415
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Although tyrosine residues in the intracellular domain of the mouse IL-7R alpha-chain (IL-7Ralpha) have been implicated in STAT5 activation, it is still unknown whether they are essential for gammadelta T cell development. | Tyrosine | signal transducer and activator of transcription 5A | Mus musculus |
| 2 | Treatment of cells with MEK1/2 inhibitors significantly decreased levels of TCRgamma germline transcription and STAT5 tyrosine phosphorylation mediated by 4R/7R-FFFF, suggesting that MEK1/2 plays an alternative role in STAT5 activation by IL-7R. | Tyrosine | signal transducer and activator of transcription 5A | Mus musculus |
| 3 | MEK1/2 associated with STAT5 and induced STAT5 tyrosine phosphorylation and DNA binding activity. | Tyrosine | signal transducer and activator of transcription 5A | Mus musculus |
| 4 | Furthermore, MEK1 directly phosphorylated a STAT5 tyrosine residue in vitro. | Tyrosine | signal transducer and activator of transcription 5A | Mus musculus |
| 5 | These results demonstrate that MEK1/2 induces TCRgamma germline transcription by phosphorylating STAT5 through IL-7R-FFFF and suggest a potential role for MAPK in IL-7R tyrosine-independent activation of STAT5. | Tyrosine | signal transducer and activator of transcription 5A | Mus musculus |