Title : Interactions between the vascular peptide endothelin-1 and sensory neuropeptides in gastric mucosal injury.

Pub. Date : 1991 Apr

PMID : 1855123






2 Functional Relationships(s)
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1 Capsaicin-pretreatment, two weeks earlier to deplete sensory neuropeptides from primary afferent neurones, augmented the mucosal damage induced by ET-1, as assessed by both macroscopic and histological examination. Capsaicin endothelin 1 Rattus norvegicus
2 The damage induced by threshold doses of ET-1 alone or in capsaicin-pretreated rats was further enhanced by administration of indomethacin (5 mg kg-1, i.v. Capsaicin endothelin 1 Rattus norvegicus