Title : Relationship between CYP2C8 genotypes and diclofenac 5-hydroxylation in healthy Spanish volunteers.

Pub. Date : 2008 Oct

PMID : 18548238






3 Functional Relationships(s)
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1 RESULTS: The diclofenac/5-hydroxydiclofenac urinary concentration ratio was higher in individuals carrying a CYP2C8*3 or CYP2C8*4 allele than in those homozygous for wild-type allele CYP2C8*1 (P < 0.05). 5-hydroxydiclofenac cytochrome P450 family 2 subfamily C member 8 Homo sapiens
2 RESULTS: The diclofenac/5-hydroxydiclofenac urinary concentration ratio was higher in individuals carrying a CYP2C8*3 or CYP2C8*4 allele than in those homozygous for wild-type allele CYP2C8*1 (P < 0.05). 5-hydroxydiclofenac cytochrome P450 family 2 subfamily C member 8 Homo sapiens
3 RESULTS: The diclofenac/5-hydroxydiclofenac urinary concentration ratio was higher in individuals carrying a CYP2C8*3 or CYP2C8*4 allele than in those homozygous for wild-type allele CYP2C8*1 (P < 0.05). 5-hydroxydiclofenac cytochrome P450 family 2 subfamily C member 8 Homo sapiens