Title : When administered to rats in a cold environment, 3,4-methylenedioxymethamphetamine reduces brown adipose tissue thermogenesis and increases tail blood flow: effects of pretreatment with 5-HT1A and dopamine D2 antagonists.

Pub. Date : 2008 Jul 17

PMID : 18534763






2 Functional Relationships(s)
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1 When administered to rats in a cold environment, 3,4-methylenedioxymethamphetamine reduces brown adipose tissue thermogenesis and increases tail blood flow: effects of pretreatment with 5-HT1A and dopamine D2 antagonists. N-Methyl-3,4-methylenedioxyamphetamine 5-hydroxytryptamine receptor 1A Rattus norvegicus
2 Our results demonstrate that MDMA in a cold environment reduces core body temperature by inhibiting iBAT thermogenesis and tail artery vasoconstriction and suggest that mechanisms by which this occurs include the activation of 5-HT1A and dopamine D2 receptors. N-Methyl-3,4-methylenedioxyamphetamine 5-hydroxytryptamine receptor 1A Rattus norvegicus