Title : Melatonin inhibits amphetamine-induced nitric oxide synthase mRNA overexpression in microglial cell lines.

Pub. Date : 2008 Jul 11

PMID : 18524487






2 Functional Relationships(s)
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1 Pretreatment with either S-methylisothiourea (S-MT), a selective iNOS inhibitor, or melatonin, a major secretory product of pineal gland, counteracted the over expression of iNOS induced by AMPH in a concentration-dependent manner. S-methylisothiopseudouronium nitric oxide synthase 2 Rattus norvegicus
2 Pretreatment with either S-methylisothiourea (S-MT), a selective iNOS inhibitor, or melatonin, a major secretory product of pineal gland, counteracted the over expression of iNOS induced by AMPH in a concentration-dependent manner. S-methylisothiopseudouronium nitric oxide synthase 2 Rattus norvegicus