Pub. Date : 2008 Nov 1
PMID : 18521936
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | C-jun N-terminal kinase regulates the interaction between 14-3-3 and Bad in ethanol-induced cell death. | Ethanol | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 2 | Activation of the c-jun N-terminal kinase (JNK) is known to be an important step during ethanol-induced cell death, but it has yet to be identified how JNK regulates apoptosis. | Ethanol | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 3 | Activation of the c-jun N-terminal kinase (JNK) is known to be an important step during ethanol-induced cell death, but it has yet to be identified how JNK regulates apoptosis. | Ethanol | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 4 | Therefore, we investigated the mechanism by which JNK induces cell death following ethanol treatment. | Ethanol | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 5 | Ethanol exposure induced phosphorylation of JNK but did not affect the expression levels of pro- and antiapoptotic proteins. | Ethanol | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 6 | Furthermore, interactions of phospho-JNK (p-JNK) with 14-3-3 as well as with Bad were enhanced in the cerebral cortices of ethanol-treated rats. | Ethanol | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 7 | Furthermore, interactions of phospho-JNK (p-JNK) with 14-3-3 as well as with Bad were enhanced in the cerebral cortices of ethanol-treated rats. | Ethanol | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 8 | Pretreatment with JNK inhibitor (SP600125) of SH-SY5Y cells inhibited JNK phosphorylation and interaction between p-JNK and 14-3-3 resulting from ethanol. | Ethanol | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 9 | We hypothesize that JNK may play an important role during ethanol-induced cell death via the inhibition of antiapoptotic function of 14-3-3 as well as activation of proapoptotic function of Bad. | Ethanol | mitogen-activated protein kinase 8 | Rattus norvegicus |