Title : Clinicopathologic characteristics, CpG island methylator phenotype, and BRAF mutations in microsatellite-stable colorectal cancers without chromosomal instability.

Pub. Date : 2008 Jun

PMID : 18517279






1 Functional Relationships(s)
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1 OBJECTIVE: To determine whether the CpG island methylator phenotype (CIMP) pathway, characterized by simultaneous methylation of several known tumor suppressor genes, is the principal underlying mechanism in cases without chromosomal or microsatellite instability, and to determine the significance of CIMP pathway and BRAF mutations in microsatellite-stable (MSS) cases. Cyclic IMP B-Raf proto-oncogene, serine/threonine kinase Homo sapiens