Title : EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers.

Pub. Date : 2008 Jun

PMID : 18511942






1 Functional Relationships(s)
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1 The polyphenol (-)-epigallocatechin gallate efficiently inhibits the fibrillogenesis of both alpha-synuclein and amyloid-beta by directly binding to the natively unfolded polypeptides and preventing their conversion into toxic, on-pathway aggregation intermediates. Polyphenols synuclein alpha Homo sapiens