Pub. Date : 2008 Jul 1
PMID : 18508033
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GSK3beta and endoplasmic reticulum stress mediate rotenone-induced death of SK-N-MC neuroblastoma cells. | Rotenone | glycogen synthase kinase 3 beta | Homo sapiens |
| 2 | We showed that rotenone activated GSK3beta by enhancing its phosphorylation at tyrosine 216 while inhibiting phosphorylation at serine 9. | Rotenone | glycogen synthase kinase 3 beta | Homo sapiens |
| 3 | Inhibitors of GSK3beta and dominant negative (kinase deficient) GSK3beta partially protected SK-N-MC cells against rotenone cytotoxicity. | Rotenone | glycogen synthase kinase 3 beta | Homo sapiens |
| 4 | Inhibitors of GSK3beta and dominant negative (kinase deficient) GSK3beta partially protected SK-N-MC cells against rotenone cytotoxicity. | Rotenone | glycogen synthase kinase 3 beta | Homo sapiens |
| 5 | Taken together, the results suggest that GSK3beta activation and ER stress contribute separately to rotenone cytotoxicity. | Rotenone | glycogen synthase kinase 3 beta | Homo sapiens |