Title : Pyrogallol as a glutathione depletor induces apoptosis in HeLa cells.

Pub. Date : 2008 Jun

PMID : 18506365






3 Functional Relationships(s)
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1 In addition, the recovery of GSH depletion by SOD and catalase was accompanied by the decrease of apoptosis levels. Glutathione superoxide dismutase 1 Homo sapiens
2 Furthermore, NAC and SOD significantly inhibited CMF-negative (GSH-depleted) and PI-positive cells induced by pyrogallol. Glutathione superoxide dismutase 1 Homo sapiens
3 Taken together, pyrogallol potently increased intracellular O2(.-) levels and decreased GSH content in HeLa cells, and NAC, SOD and catalase significantly rescued HeLa cells from pyrogallol-induced apoptosis accompanied by the recovery of GSH depletion. Glutathione superoxide dismutase 1 Homo sapiens