Title : Mechanistic studies on ADAMTS13 catalysis.

Pub. Date : 2008 Sep

PMID : 18502798






2 Functional Relationships(s)
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Protein Name
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1 Hydrolysis by ADAMTS13 of a VWF analog (Asp(1596)-Arg(1668) peptide, fluorescence energy transfer substrate [FRETS]-VWF73) was investigated by a fluorescence quenching method (FRETS method) from 15 degrees C to 45 degrees C and pH values from 4.5 to 10.5. Arginine von Willebrand factor Homo sapiens
2 The interaction of the Met(1606)-Arg(1668) region of VWF with ADAMTS13 involves basic residues of the protease and is thus progressively inhibited at pH values >8.50. Arginine von Willebrand factor Homo sapiens