Title : Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13.

Pub. Date : 2008 May 27

PMID : 18492805






1 Functional Relationships(s)
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1 We now show that, under shear stress and at physiological pH and ionic strength, coagulation factor VIII (FVIII) accelerates, by a factor of approximately 10, the rate of specific cleavage at the Tyr(1605)-Met(1606) bond in VWF. Tyrosine von Willebrand factor Homo sapiens