Title : Therapeutic strategies for targeting BRAF in human cancer.

Pub. Date : 2007 May

PMID : 18473997






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The first generation of RAF inhibitors, including sorafenib, were notable for their lack of specificity and potency for RAF and these agents have shown limited efficacy in tumors with a high incidence of BRAF mutation such as melanoma. Sorafenib B-Raf proto-oncogene, serine/threonine kinase Homo sapiens