Title : Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system.

Pub. Date : 2008 Sep

PMID : 18472021






1 Functional Relationships(s)
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1 The plasma lysophospholipid mediator sphingosine-1-phosphate (S1P) is produced exclusively by sphingosine kinase (SPHK) 1 and SPHK2 in vivo, and plays diverse biological and pathophysiological roles by acting largely through three members of the G protein-coupled S1P receptors, S1P1, S1P2 and S1P3. sphingosine 1-phosphate sphingosine-1-phosphate receptor 1 Rattus norvegicus