Pub. Date : 2008 Jul 15
PMID : 18466776
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MsrA knockout mouse exhibits abnormal behavior and brain dopamine levels. | Dopamine | methionine sulfoxide reductase A | Mus musculus |
| 2 | Surprisingly, relative to wild-type mice, MsrA(-/-) brains contained significantly higher levels of dopamine up to 12 months of age, while lower levels of dopamine were observed at 16 months of age. | Dopamine | methionine sulfoxide reductase A | Mus musculus |
| 3 | Moreover, striatal regions of MsrA(-/-) mice showed an increase of dopamine release parallel to observed dopamine levels. | Dopamine | methionine sulfoxide reductase A | Mus musculus |
| 4 | Moreover, striatal regions of MsrA(-/-) mice showed an increase of dopamine release parallel to observed dopamine levels. | Dopamine | methionine sulfoxide reductase A | Mus musculus |
| 5 | Thus, it is suggested that dopamine regulation and signaling pathways are impaired in MsrA(-/-) mice, which may contribute to their abnormal behavior. | Dopamine | methionine sulfoxide reductase A | Mus musculus |