Title : Role of Ca2+ influx in bombesin-induced mitogenesis in Swiss 3T3 fibroblasts.

Pub. Date : 1991 Jan 25

PMID : 1846353






1 Functional Relationships(s)
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1 Bombesin induces the same extent of phosphorylation of MARCKS protein, the major cellular substrate for protein kinase C, irrespective of the medium calcium concentration for at least 4 h. Moreover, diverse cellular responses elicited by bombesin, including c-fos expression, activation of microtubule-associated protein 2 kinase and S6 kinase, glucose uptake, and protein synthesis but not the release of arachidonic acid and its metabolites, are induced similarly at either 0.03 or 3.0 mM calcium. Arachidonic Acid gastrin releasing peptide Homo sapiens