Title : p53 Cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo.

Pub. Date : 2009 Jan

PMID : 18459128






1 Functional Relationships(s)
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1 The berberine-induced apoptosis of both the A549 and H1299 human lung cancer cells was associated with the disruption of mitochondrial membrane potential, reduction in the levels of Bcl-2, Bcl-xl while increase in Bax, Bak, and activation of caspase-3. Berberine BCL2 apoptosis regulator Homo sapiens