Title : Constitutive activation of the N-methyl-D-aspartate receptor via cleft-spanning disulfide bonds.

Pub. Date : 2008 Aug 1

PMID : 18450751






1 Functional Relationships(s)
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1 Two mutants, E522C/I691C in NR1 (EI) and K487C/N687C in NR2 (KN) were found to exhibit significant glycine- and glutamate-independent activation, respectively, and co-expression of the two subunits produced a constitutively active channel. Glycine glutamate ionotropic receptor NMDA type subunit 1 Homo sapiens