Pub. Date : 2008 Jul
PMID : 18448631
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we demonstrate that histamine inhibits KCNQ2/Q3 currents in human embryonic kidney (HEK)293 cells via phosphatidylinositol 4,5-bisphosphate (PIP(2)) hydrolysis mediated by stimulation of H(1) receptor and phospholipase C (PLC). | Histamine | potassium voltage-gated channel subfamily Q member 2 | Homo sapiens |
| 2 | Histamine inhibited KCNQ2/Q3 currents in HEK293 cells coexpressing H(1) receptor, and this effect was totally abolished by H(1) receptor antagonist mepyramine but not altered by H(2) receptor antagonist cimetidine. | Histamine | potassium voltage-gated channel subfamily Q member 2 | Homo sapiens |
| 3 | The inhibitory effect of histamine on KCNQ2/Q3 currents was entirely reversible but became irreversible when the resynthesis of PIP(2) was impaired with phosphatidylinsitol-4-kinase inhibitors. | Histamine | potassium voltage-gated channel subfamily Q member 2 | Homo sapiens |