Protein Name | potassium voltage-gated channel subfamily Q member 2 |
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Organism | Homo sapiens |
Gene ID | 3785 |
Gene Symbol | KCNQ2 |
UniProt | O43526 (KCNQ2_HUMAN), Q53Y30 (Q53Y30_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
157
Total Number of Articles : 194 |
Description |
potassium voltage-gated channel subfamily Q member 2 |
Gene Summary |
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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